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Volume 23 , Issue 27 , 2017 J Physiol Pharmacol

In rodent models of varicocele, histological changes include degeneration of the spermatogenic epithelium, disruption of seminiferous tubule architecture, inflammatory-cell infiltration, and increased oxidative stress within the testicular tissue ( The causal involvement of TNF- signaling in this inflammatory cascade has been further supported by gene-knockout evidence (9294)

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